Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows,Pimephales promelas
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چکیده
منابع مشابه
Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, Pimephales promelas
Perchlorate is a known environmental contaminant, largely due to widespread military use as a propellant. Perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear. Our studies aimed to investigate the effects of concentrations of ammo...
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We examined indices of thyroid development in tadpoles from ammonium perchlorate (AP)-exposed sites. Bullfrog (Rana catesbeiana) tadpoles collected from a reference site exhibited normal developmental features, with many completing metamorphoses. In contrast, tadpoles collected from the AP contaminated site exhibited a 5-fold lower hindlimb/snout-vent length ratio than tadpoles from the referen...
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Stimulatory effects of yeast beta-1,3-1,6-glucans on neutrophils have long been recognized, but effects of glucans on degranulation of primary granules in fish neutrophils have not been previously reported. Neutrophil function was monitored during in vitro and in vivo application of glucans to non- (NS), acute- (AS) and chronically stressed (CS) fish. beta-Glucan proved to be a strong and quick...
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The impact of low level dust on the thyroid function of workers chronically exposed to ammonium perchlorate (AP) is uncertain and controversial. The aim of this study was to examine whether workers in China with long-term (>3 years) occupational exposure to low levels of AP dust had affected thyroid homeostasis. Mean occupational exposures to AP dust ranged from 0.43 to 1.17 mg/m3. Geometric me...
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Many chemicals that adversely affect reproduction and/or development do so through multiple pathways within the reproductive tract and hypothalamic-pituitary-gonadal axis. Notable in this regard are fungicides, such as prochloraz or fenarimol, which in mammals have the potential to impact endocrine function through inhibition of CYP enzymes involved in steroid metabolism, as well as through ant...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2005
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.7333